Most photographers treat the Portra family like a single film in three sensitivity settings. Box speed goes up, you use it in darker conditions, done. That's not really what's happening.
Each stock has a distinct character. The differences show up in grain, in how the shadows behave, in the way skin tones render. If you're building presets or trying to match a specific look, treating them as interchangeable will get you close but not there.
Portra 160
This is the sharpest, most neutral of the three. Grain is fine enough to be almost invisible at most print sizes. Colors are accurate without being clinical, skin reads as skin rather than a warmed-up approximation of skin. Shadows have detail and stay relatively clean rather than shifting color.
It was designed for controlled shooting: studio work, daylight portraits, situations where you have time to meter properly. The tradeoff is no latitude for error. Underexpose Portra 160 and you lose shadow detail fast. It doesn't rescue you the way 400 does.
In Lightroom terms, the base curve is fairly linear. Highlights roll off gently but the shadows don't lift much. Grain is fine and mostly luminance-based, with very little color grain. If you're building a 160 emulation, resist the urge to add warmth. The neutrality is the point.
Portra 400
This is the one photographers mean when they say "the Portra look." It's warmer than 160, noticeably so in the highlights and midtones. Shadows are lifted slightly and push toward green-teal in a way that reads as organic rather than filtered. The grain is more present but still structured, clumping slightly, which gives it texture without looking noisy.
It also has more exposure latitude than 160. You can overexpose Portra 400 by two stops and get blown highlights that still hold a creamy quality. That overexposed look is partly what people are chasing when they ask for "the film look" without being able to say exactly what they mean.
For presets: warm the highlights, lift the shadows and pull them toward teal, add grain with some color variation baked in. The highlight warmth is more important than most people realize. It's what separates a convincing 400 emulation from one that just looks like a slightly processed digital file.
Portra 800
Here's where it gets interesting. Portra 800 isn't Portra 400 pushed two stops. Kodak formulated it as a separate emulsion with a different grain structure and different color response, particularly in how it handles mixed and artificial light.
The grain is coarser and has more color variation. You'll see actual chroma grain, not just luminance texture. Shadows go murkier and cooler. The highlight roll-off is more compressed, which can look either cinematic or slightly muddy depending on how you expose. Skin tones shift slightly toward magenta compared to 400.
It also handles tungsten and fluorescent light differently. Where 400 tends to go green-yellow under artificial light, 800 can go more magenta-pink. That's a meaningful difference if you're shooting events or low-light portraits.
Preset approach: add real chroma grain, cool the shadows further than 400, compress the highlights more aggressively. The color shift under artificial light is hard to replicate with a single preset, so if that's the look you're after, you may need separate versions for daylight and indoor use.
The practical answer
If you're choosing between them for a look rather than a lighting condition:
Portra 160 is for when you want film character without film drama. Clean, accurate, slightly elevated above digital but not shouting about it.
Portra 400 is the safe default. The warmth and the lifted shadows flatter most subjects in most light. There's a reason it became the reference point for the whole aesthetic.
Portra 800 is for specific situations or specific clients. The grain, the color shifts, the compressed highlights read as intentional when they work and as a mistake when they don't. It's a more opinionated stock and it requires a more opinionated edit.
The main thing to take from this: if your preset pack treats all three as the same with different grain amounts, it's missing most of what distinguishes them.